Abstract 71: Characterizing The Contribution Of Circulating Mesenchymal Cells To Pathologic Wound Healing And Heterotopic Ossification
نویسندگان
چکیده
F ray, M ay 5, 2017 PURPOSE: Acquired hypoparathyroidism is most commonly caused by surgical removal or iatrogenic injury. Permanent hypoparathyroidism occurs in up to 5% of patients undergoing total thyroidectomy or neck dissection, which can result in profound hypocalcemia. If injury is noted intraoperatively the parathyroid gland can be minced and implanted subcutaneously to recover function. Frequently, the manifestations of hypoparathyroidism are only discovered postoperatively when symptoms of calcium and phosphorus dysregulation are noted. Medical management is required to prevent tetany, bone loss, and possibly death. Adipose derived stem cells (ADSCs) are multipotent mesenchymal stem cells which may offer an autologous treatment for this chronic condition. We hypothesize that ADSCs can be converted into functional parathyroid cells in vitro, which could be utilized for delayed subcutaneous implantation and correction of hypoparathyroidism.
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